Selective Binding of Albumin to Gm1 Ganglioside Micelles Containing Paclitaxel
نویسندگان
چکیده
منابع مشابه
Anti-idiotypic monoclonal antibodies to GM1 identify ganglioside binding proteins.
Ganglioside stimulated neurite outgrowth may be due to ganglioside binding to membrane proteins or to intercalation into the membrane. To test that ganglioside binding proteins could be found on neuronal surfaces, anti-idiotypic ganglioside monoclonal antibodies (AIG mAbs) were generated to mimic the biological properties of the GM1 ganglioside. The AIG mAbs were identified by their ability to ...
متن کاملCholera toxin assault on lipid monolayers containing ganglioside GM1.
Many bacterial toxins bind to and gain entrance to target cells through specific interactions with membrane components. Using neutron reflectivity, we have characterized the structure of mixed DPPE:GM(1) lipid monolayers before and during the binding of cholera toxin (CTAB(5)) or its B-subunit (CTB(5)). Structural parameters such as the density and thickness of the lipid layer, extension of the...
متن کاملGanglioside GM1 Binding Peptides: A Potential Adjuvant for Transcutaneous Immunization
Cholera toxin (CT) binds ganglioside GM1 and has been used as an adjuvant in transcutaneous immunization. To determine if the adjuvant property of CT was merely due to binding to ganglioside GM1, mice were immunized by the transcutaneous route using hen egg lysozyme (HEL) as the antigen, and either CT or synthetic peptides that bind to ganglioside GM1 as the adjuvant, and the immune responses w...
متن کاملBiochemical characterization of the interactions between doxorubicin and lipidic GM1 micelles with or without paclitaxel loading
Doxorubicin (Dox) is an anthracycline anticancer drug with high water solubility, whose use is limited primarily due to significant side effects. In this study it is shown that Dox interacts with monosialoglycosphingolipid (GM1) ganglioside micelles primarily through hydrophobic interactions independent of pH and ionic strength. In addition, Dox can be incorporated even into GM1 micelles alread...
متن کاملTrial of ganglioside GM1 in acute stroke.
Ganglioside GM1 (100 mg) was given daily by intramuscular injection for 28 days in a double-blind placebo controlled trial of acute stroke. No significant difference was detected in a 6 month follow-up period between well matched control and active groups. Although the number of patients studied was small the findings are believed to indicate that GM1 is unlikely to be of value in the treatment...
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ژورنال
عنوان ژورنال: Journal of Nanomedicine & Nanotechnology
سال: 2012
ISSN: 2157-7439
DOI: 10.4172/2157-7439.1000159